The Nathanson Lab focuses on malignant gliomas, some of the most lethal of all cancers. Using a suite of tools, including innovative molecularly characterized patient-derived orthotopic glioma xenografts (PDOX), molecular imaging (e.g., PET imaging), and nanotechnology for interrogating single cells, our lab has a specific interest in investigating the dynamic interplay between specific genetic alterations and critical functional processes (e.g., signaling, apoptosis, metabolism) in malignant gliomas. Through close collaborations with UCLA Neuro-Oncology, UCLA Chemistry, and Caltech, our ultimate goal is to develop new therapeutic strategies that can be translated into improved outcomes for patients with malignant brain cancer.
NEWS: Our graduate student Wilson Mai just published his paper “Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma” in Nature Medicine. Read more here…
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