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Caius Radu, MD

Dr. Radu is Professor and Vice Chairman of the Department of Molecular and Medical Pharmacology for Graduate Education. Dr. Radu received his M.D. from the University of Medicine, Craiova, Romania and did his postdoctoral training at UTSW Medical Center in Dallas (with Dr. Sally Ward) and at UCLA (with Dr. Owen Witte). His group uses a multidisciplinary approach that integrates biology, chemistry, pharmacology and molecular imaging to translate basic insights into metabolic regulation of immune cells and cancer cells into new therapeutics and diagnostics.

Publications

  1. Medesan, C., Radu, C.G., Kim, J-K., Ghetie, V. and Ward, E.S. Localization of the site of the IgG molecule that regulates materno-fetal transmission in mice. Eur. J. Immunol. 26, 2533-2536, 1996.
  2. Medesan, C., Matesoi, D., Radu, C.G, Ghetie, V. and Ward, E.S. Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG. J. Immunol. 158, 2211-2217, 1997.
  3. Ghetie, V., Popov, S., Borvak, J., Radu, C.G., Matesoi, D., Medesan, D., Ober, R.J. and Ward, E.S. Increasing the serum persistence of an IgG fragment by random mutagenesis. Nature Biotech., 15, 637-640, 1997.
  4. Borvak, J., Richardson, J., Medesan, C., Antohe, F., Radu, C.G., Simionescu, M., Ghetie, V. and Ward, E.S. Functional expression of the MHC class I related receptor, FcRn, in endothelial cells of mice. Int. Immunol., 10, 1289-1298, 1998.
  5.  Radu, C.G., Ober, B.T., Colantonio, L., Qadri, A., and Ward, E.S. Expression and characterization of soluble peptide: I-A complexes associated with murine experimental autoimmune diseases. J. Immunol., 160, 5915-5921, 1998.
  6.  Qadri, A., Thatte, J., Radu, C.G., Ober, B.T., and Ward, E.S. A T cell receptor V, domain binds to MHC class II: possible role in immunoregulation and T cell selection. Int. Immunol., 11, 968-977, 1999.
  7. Thatte, J., Qadri, A., Radu, C.G., and Ward, E.S. Molecular requirements for T cell recognition by an MHC class II restricted T cell receptor: the involvement of the fourth hypervariable loop of the V domain. J. Exp. Med., 189, 509-519, 1999.
  8. Kim J-K., Firan M., Radu C.G., Kim C-H., Ghetie V., and Ward, E.S. Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn. Eur. J. Immunol., 29, 2819-2825, 1999.
  9.  Schuck, P., Radu C.G., and Ward, E.S. Sedimentation equilibrium analysis of recombinant mouse FcRn with murine IgG1. Mol. Immunol., 36, 1117-1125, 1999.
  10. Qadri, A., Radu, C.G., Thatte, J., Cianga, P., Ober, B.T., Ober, R.J., and Ward, E.S. A role for the region encompassing the c” strand of a T cell receptor V domain in T cell activation events. J. Immunol., 165:820-829, 2000.
  11. Radu, C.G., Anderton, S.M., Firan, M., Wraith, D.C. and Ward, E.S. Detection of autoreactive T cells in H-2u mice using peptide-MHC multimers. Int. Immunol., 12, 1553-1560, 2000.
  12. Anderton, S.M., Radu, C.G., Lowrey, P.A., Ward, E.S., and Wraith, D.C. Negative Selection during the Peripheral Immune Response to Antigen. J. Exp. Med., 193, 1-12, 2001.
  13. Garcia, C.K., Radu, C.G., Ho, J., Ober, R.J., Ward, E.S. Kinetics and thermodynamics of T cell receptor-autoantigen interactions in murine experimental autoimmune encephalomyelitis. PNAS., 98, 6818-23, 2001.
  14. Firan, M., Bawdon, R., Radu, C.G., Ober, R.J., Eaken, D., Antohe, F., Ghetie, V., and Ward, E.S. The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans. Int. Immunol. 13, 993-1002, 2001.
  15. Ober, R.J., Radu, C.G., Ghetie, V., and Ward, E.S., Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol  13:1551-9, 2001.
  16. Deng, C., Minguela, A., Hussain, R.Z., Lovett-Racke, A.E., Radu, C.G., Ward, E.S., and Racke, M.K. Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis. J.  Immunol. 168:4511-8, 2002.
  17.  He, X.L., Radu, C.G., Sidney, J., Sette, A, Ward, E.S., Garcia, K.C. Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au. Immunity 17:83-94, 2002.
  18. Deng, C., Radu, C.G., Diab, A., Tsen, M.F., Hussain, R., Cowdery, J.S., Racke, M.K. and Thomas, J.A. IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity. J. Immunol. 170:2833-42, 2003.
  19. Radu, C.G., Yang, L.V., Riedinger, M., Au, M., Witte, O.N. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. PNAS. 2004 Jan 6;101(1):245-50. Epub 2003 Dec 17.
  20. Yang, L.V., Radu, C.G., Wang, L., Riedinger, M., Witte, O.N. Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. Blood. 2005 Feb 1;105(3):1127-34. Epub 2004 Sep 21.
  21. Radu, C.G., Nijagal, A., McLaughlin, J., Wang, L., Witte, O.N. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. PNAS. 2005 Feb 1;102(5):1632-7. Epub 2005 Jan 21.
  22. Wang, Li, Radu, C.G., Yang, L.V., Bentolila, L.A., Riedinger, M., and Witte, O.N Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G-protein-coupled receptor G2A, Mol Biol Cell. Epub 2005 Feb 23.
  23. Shu, C. J., Guo, S., Kim, J.Y., Shelly, S., Ray, P., Gambhir, S.S., Radu, C.G., and Witte, O. N., Visualization of a primary anti-tumor immune response by positron emission tomography. PNAS.  2005 Nov 29;102(48):17412-7. Epub 2005 Nov 17.
  24. Radu, C.G., Cheng, D., Nijagal, A., Riedinger, M., McLaughlin, J., Yang, L.V, Johnson, J., and Witte, O. N. Normal Immune Development and Glucocorticoid-induced Thymocyte Apoptosis in Mice Deficient for the T cell Death-Associated Gene-8 Receptor, Mol Cell Biol. 2006 Jan;26(2):668-77.
  25. Yang, L.V., Radu, C.G., Roy, M., Sunyoung Lee, S., McLaughlin, J., Michael A. Teitell, M.A.,  M. Luisa Iruela-Arispe, M.L., and Witte, O.N. Vascular Abnormalities in Mice Deficient for the G Protein-Coupled Receptor GPR4 That Functions as a pH Sensor. Mol Cell Biol. 2007 Feb;27(4):1334-47. Epub 2006 Dec 4.
  26. Radu CG, Shu CJ, Shelly SM, Phelps ME, Witte ON. Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1937-42. Epub 2007 Jan 29. Comment in Cell Volume 128, Issue 5, 9 March 2007, Pages 807, 809
  27. Bailey, R.C., Kwong, G.A, Radu, C.G., Witte, O.N., Heath, J.R. DNA-Encoded Antibody Libraries: A Unified Platform for Multiplexed Cell Sorting and Detection of Genes and Proteins. J Am Chem Soc. 2007 Jan 30;
  28. Huang JH, Cárdenas-Navia LI, Caldwell CC, Plumb TJ, Radu CG, Rocha PN, Wilder T, Bromberg JS, Cronstein BN, Sitkovsky M, Dewhirst MW, Dustin ML. Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol. 2007 Jun 15;178(12):7747-55.
  29. McLaughlin J, Cheng D, Singer O, Lukacs RU, Radu CG, Verma IM, Witte ON. Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20501-6. Epub 2007 Dec 13.
  30. Peter C, Waibel M, Radu CG, Yang LV, Witte ON, Schulze-Osthoff K, Wesselborg S, Lauber K. Migration to apoptotic ‘Find-Me’ signals is mediated via the phagocyte receptor G2A. J Biol Chem. 2007 Dec 18 [Epub ahead of print]
  31. Nair-Gill, Shu CJ, Radu CG, Witte ON. Non-invasive imaging of adaptive immunity using positron emission tomography. Immunol Rev. 2008 Feb; 221:214-28.
  32. Prins RM, Shu CJ, Radu CG, Vo DD, Khan-Farooqi H, Soto H, Yang MY, Lin MS, Shelly S, Witte ON, Ribas A, Liau LM. Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain. Cancer Immunol Immunother. 2008 Feb 6
  33. Tumeh PC, Radu CG, Ribas A. PET imaging of cancer immunotherapy. J Nucl Med. 2008 Jun;49(6):865-8. Review
  34. Radu CG (co-corresponding author), Shu CJ, Nair-Gill E, Shelly SM, Barrio JR, Satyamurthy N, Phelps ME, Witte ON, Molecular imaging of lymphoid organs and immune activation using positron emission tomography with a new 18F-labeled 2’-deoxycytidine analog. Nat Med. 2008 Jul;14(7):783-8. Epub 2008 Jun 8.
  35. Wei LH, Olafsen T, Radu C, Hildebrandt IJ, McCoy MR, Phelps ME, Meares C, Wu AM, Czernin J, Weber WA. Engineered antibody fragments with infinite affinity as reporter genes for PET imaging. J Nucl Med. 2008 Nov;49(11):1828-35. Epub 2008 Oct 16. PMID: 18927335
  36. Shu CJ, Radu CG, Shelly SM, Vo DD, Prins R, Ribas A, Phelps ME, Witte ON. Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen. Int Immunol. 2008 Dec 23. PMID: 19106231
  37. Laing RE, Walter MA, Campbell DO, Herschman HR, Satyamurthy N, Michael E. Phelps ME, Czernin J, Witte ON, Radu CG. Noninvasive Prediction of Tumor Responses to Gemcitabine Using Positron Emission Tomography, Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2847-52. Epub 2009 Feb 5. PMID: 19196993
  38. Yu ZT, Kamei KI, Takahashi H, Shu CJ, Wang X, He GW, Silverman R, Radu CG, Witte ON, Lee KB, Tseng HR. Integrated microfluidic devices for combinatorial cell-based assays. Biomed Microdevices. 2009 Jan 9. PMID: 19130244
  39. Wang H, Wang S, Su H, Chen KJ, Armijo AL, Lin WY, Wang Y, Sun J, Kamei K, Czernin J, Radu CG, Tseng HR. A supramolecular approach for preparation of size-controlled nanoparticles. Angew Chem Int Ed Engl. 2009;48(24):4344-8.PMID: 19425037
  40. Kwong GA, Radu CG, Hwang K, Shu CJ, Ma C, Koya RC, Comin-Anduix B, Hadrup SR, Bailey RC, Witte ON, Schumacher TN, Ribas A, Heath JR. Modular Nucleic Acid Assembled p/MHC Microarrays for Multiplexed Sorting of Antigen-Specific T Cells. J Am Chem Soc. 2009 Jun 24. [Epub ahead of print] PMID: 19552409
  41. Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, Witte ON, Khurana Hershey GK, Rothenberg ME, Zimmermann N. Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood. 2009 Sep 24;114(13):2774-82. Epub 2009 Jul 29. PMID: 19641187
  42. Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, Czernin J, Shyy JY, Watson AD, Phelps M, Radu CG, Cloughesy TF, Mischel PS. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12932-7. Epub 2009 Jul 22. PMID: 19625624
  43. Laing RE, Nair-Gill E, Witte ON, Radu CG. Visualizing cancer and immune cell function with metabolic positron emission tomography. Curr Opin Genet Dev. 2009 Nov 18.
  44. Toy G, Austin RW*, Liao H, Cheng D, Singh AS, Campbell DO, Ishikawa T, Herschman RH, Johannes Czernin J, Witte ON, Radu CG. Impaired T and B cell development in deoxycytidine kinase deficient mice, PNAS published online before print December 31, 2009, doi:10.1073/pnas.0913900107
  45. Guo D, Cloughesy TF, Radu CG, Mischel PS; AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas. Cell Cycle. 2010 Jan 6;9(2).
  46.  Brewer S, Nair-Gill E, Wei B, Chen L, Li X, Riedinger M, Campbell DO, Wiltzius S, Satyamurthy N, Phelps ME, Radu C, Witte ON, Braun J, Uptake of [18F]1-(2′-deoxy-2′-arabinofuranosyl) Cytosine Indicates Intestinal Inflammation in Mice. Gastroenterology. 2010 Jan 14. [Epub ahead of print] PMID: 20080095 [PubMed – as supplied by publisher]
  47. Laing RE, Nair-Gill E, Witte ON, Radu CG. Visualizing cancer and immune cell function with metabolic positron emission tomography. Curr Opin Genet Dev. 2010 Feb;20(1):100-5. Review.
  48. Ribas A, Benz MR, Allen-Auerbach MS, Radu CG, Chmielowski B, Seja E, Williams JL, Gomez-Navarro J, McCarthy T, Czernin J. Imaging CTLA4 Blockade-induced Cell Replication with [18F]FLT PET in Patients with Advanced Melanoma Treated with Tremelimumab. J Nucl Med. 2010 Mar;51(3):340-6. Epub 2010 Feb 11.
  49. Nair-Gill E, Wiltzius S, Wei X, Cheng D, Radu CG, Witte ON, PET probes for distinct metabolic pathways have different cell specificities during an immune response, J Clin Invest. 2010 Jun 1;120(6):2005-15. doi: 10.1172/JCI41250. Epub 2010 May 17. PMCID: PMC2877561
  50. Rabinovich BA, Radu CG. Imaging Adoptive Cell Transfer Based Cancer Immunotherapy. Curr Pharm Biotechnol. 2010 May 24. [Epub ahead of print];
  51.  Shu CJ, Campbell DO*, Lee, JT, Tran, AT, Wengrod JC, Toy G, Phelps ME, Witte ON, Satyamurthy N, Czernin J, Radu CG. Novel PET imaging probes specific for deoxycytidine kinase, Journal of Nuclear Medicine, 2010, June 16, 2010 as doi:10.2967/jnumed.109.073361.
  52. Singh AS, Radu CG, Ribas A. PET imaging of the immune system: immune monitoring at the whole body level. Q J Nucl Med Mol Imaging. 2010 Jun 18. [Epub ahead of print]
  53. Koya RC, Mok S, Comin-Anduix B, Chodon T, Radu CG, Nishimura MI, Witte ON, Ribas A. Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14286-91. Epub 2010 Jul 12
  54. Schwarzenberg J, Radu CG, Benz M, Fueger B, Tran AQ, Phelps ME, Witte ON, Satyamurthy N, Czernin J, Schiepers C. Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway. Eur J Nucl Med Mol Imaging. 2010 Dec 3. [Epub ahead of print]
  55. Ng QK, Su H, Armijo AL, Czernin J, Radu CG, Segura T. Clustered Arg-Gly-Asp peptides enhances tumor targeting of nonviral vectors. ChemMedChem. 2011 Apr 4;6(4):623-7. doi: 10.1002/cmdc.201000541. Epub 2011 Jan 24
  56. Zheng X, Yu CL, Sha W, Radu C, Huang SC, Feng D. Study of an image-derived SUV and a modified SUV using mouse FDG-PET. Nucl Med Biol. 2011 Apr;38(3):353-62. Epub 2010 Dec 3.
  57. Ma C; Fan R; Ahmad H; Shi Q; Comin-Anduix B; Chodon T; Koya RC; Liu C-C; Kwong G; Radu CG; Ribas A; Heath JR.  A Microchip Platform for Single Cell, Multiplexed Evaluation of Immune Cell Function, Applicable to the Immune Monitoring of Immunotherapy Clinical Trials. Nat Med. 2011 Jun;17(6):738-43. Epub 2011 May 22
  58. Lee, JT, Campbell, DO, Satyamurthy, N, Czernin, Radu, CG, Stratification of nucleoside analog chemotherapy using 18F-FAC and L-18F-FMAC PET, J Nucl Med. 2012 Feb;53(2):275-80.
  59. Benz MR, Czernin J, Allen-Auerbach MS, Dry SM, Sutthiruangwong P, Spick C, Radu C, Weber WA, Tap WD, Eilber FC. 3′-deoxy-3′-[(18) F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: A pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response. Cancer. 2011 Oct 21. doi: 10.1002/cncr.26630. [Epub ahead of print] PMID: 22020872
  60. Vatakis DN, Koya, RC, Nixon, C, Wei, L, Kim, SG, Avancena, P, Bristol, G, Baltimore, D, Kohn, DB, Ribas, A, Radu, CG, Galic, Z, Zack, JA, Anti-tumor activity from antigen specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells, Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):E1408-16. Epub 2011 Nov 28.
  61. Campbell, DO, Yaghoubi, SS, Su, Y, Lee, JT, Auerbach, MS, Herschman, H, Satyamurthy, N, Czernin, J, Lavie, A, and Radu, CG, Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of a non-natural thymidine analog reporter probe, J Biol Chem. 2012 Jan 2;287(1):446-54. Epub 2011 Nov 9.
  62. Aarntzen EH, Srinivas M, Radu CG, Punt CJ, Boerman OC, Figdor CG, Oyen WJ, de Vries IJ. In vivo imaging of therapy-induced anti-cancer immune responses in humans. Cell Mol Life Sci. 2012 Oct 5. [Epub ahead of print] PMID: 23052208
  63. Yaghoubi SS, Campbell DO, Radu CG, Czernin J. Positron emission tomography reporter genes and reporter probes: gene and cell therapy applications. Theranostics. 2012;2(4):374-91. Epub 2012 Apr 10. PMID: 22509201 [PubMed]
  64. Austin WR, Armijo AL, Campbell DO, Singh AS, Hsieh T, Nathanson D, Herschman HR, Phelps ME, Witte ON, Czernin J, Radu CG. Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress, J Exp Med. 2012 Nov 19;209(12):2215-28. doi: 10.1084/jem.20121061. Epub 2012 Nov 12
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